Talking Point
BRCA1: exploring the links to transcription

https://doi.org/10.1016/S0968-0004(00)01632-7Get rights and content
Under a Creative Commons license
open archive

Abstract

Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and transcriptional regulation. Recent developments indicate that BRCA1 is a multifunctional protein, and disruption of its transcriptional activity could be crucial for tumor development.

Keywords

Biochemistry
Cell biology

Keywords

Bracai
Transcription
Breast cancer
Tumour suppressor
RNA polymerase II
BRCT domain

Cited by (0)