Review articleThe effect of insulin-like growth factors on brain myelination and their potential therapeutic application in myelination disorders
References (143)
Molecular biology of the major myelin genes
Trends Neurosci
(1986)Integrins: versatility, modulation and signaling in cell adhesion
Cell
(1992)- et al.
Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: correlation with insulin-like growth factors I and II
Neuroscience
(1993) - et al.
Expression of insulin-like growth factor-I and related peptides during motoneuron regeneration
Exp Neurol
(1994) - et al.
Expression of insulin-like growth factor binding protein-4 (IGFBP-4) by rat neural cells —comparison to other IGFBPs
Regul Pept
(1993) - et al.
Altered IGFBP-5 gene expression in the cerebellar external germinal layer of weaver mutant mice
Mol Brain Res
(1995) - et al.
Genetic ablation of IGFBP-2 suggests functional redundancy in the IGFBP family
Progr Growth Factor Res
(1995) - et al.
Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain
Mol Brain Res
(1991) - et al.
Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal development
Dev Biol
(1991) - et al.
Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures
Dev Brain Res
(1983)
Insulin-like growth factor I receptors in neuronal and glial cells
J Biol Chem
Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains
Regul Pept
Cell death and control of cell survival in the oligodendrocyte lineage
Cell
Trophic effects of insulin-like growth factor-I on fetal rat hypothalamic cells in culture
Neuroscience
Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain
Brain Res
Myelin development and nutritional insufficiency
Brain Res
Evidence for defective incorporation of proteins in myelin of the quaking mutant mouse
Brain Res
An AG → GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon
FEBS Lett
Role of the insulin-like growth factors in embryonic and postnatal growth
Cell
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type I IGF receptor (Igf1r)
Cell
Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons
Neuron
Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice
Neuron
Insulin-like growth factor-I influences the initiation of myelination: studies of the anterior commissure of transgenic mice
Neurosci Lett
Human insulin-like growth factor binding protein-1 (hIGFBP-1) transgenic mice: insights into hIGFBP-1 regulation and actions
Prog Growth Factor Res
Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice
Progr Growth Factor Res
Nutritional regulation of somatomedin
Am J Clin Nutr
Circulating levels of insulin-like growth factors I & II and somatomedin B in alcoholic patients
Psych Res
Somatomedins in aging and dementia disorders of the Alzheimer type
Neurobiol Aging
Insulin-like growth factors in the response to cerebral ischemia
Mol Cell Neurosci
A role for IGF-I in the rescue of CNS neurons following hypoxic-ischemic injury
Biochem Biophys Res Commun
Expression of insulin-like growth factor-I by astrocytes in responses to injury
Brain Res
Pelizaeus-Merzbacher disease: an X-linked neurologic disorder of myelin metabolism with a novel mutation in the gene encoding proteolipid protein
Am J Hum Genet
Multiple sclerosis
Ann Rev Neurosci
The oligodendrocyte-type-2 astrocyte cell lineage is specialized for myelination
Nature
Glial cell diversification in the rat optic nerve
Science
Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons
Nature
The role of the insulin-like growth factors in the nervous system
The biological role of truncated insulin-like growth factor-1 and the tripeptide GPE in the central nervous system
nsulin-like growth factors in the central nervous system: biosynthesis and biological role
Transient IGF-I gene expression during the maturation of functionally related central projec-tion neurons
Neuroscience
Cellular pattern of type-1 insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II
Neuroscience
Molecular biology of the insulin-like growth factors: relevance to nervous system function
Molec Neurobiol
Patterns of insulin-like growth factor and IGF receptor gene expression in the brain
Ann NY Acad Sci
Expression and synthesis of insulin-like growth factor (IGF)-I,-II and their receptors in human glioma cell lines
Int J Oncol
Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin
Endocrinology
Autoradiographic localization of insulin-like growth factor n receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice
Brain Res
Insulin-like growth factor binding protein-1 stimulates cell migration and binds to the α5βN1 integrin by means of its Arg-Gly-Asp sequence
Insulin-like growth factors and their binding protein: biological actions
Endocrin Rev
Demonstration of membrane-bound insulin-like growth factorbinding proteins in human glioma cell lines
Int J Oncol
Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I expression during brain development
J Neurosci
Cited by (31)
Myelination Events
2018, Volpe's Neurology of the NewbornInsulin-like growth factor-1 provides protection against psychosine-induced apoptosis in cultured mouse oligodendrocyte progenitor cells using primarily the PI3K/Akt pathway
2005, Molecular and Cellular NeuroscienceCitation Excerpt :The therapeutic potential of insulin-like growth factor-1 (IGF-1) in the treatment of demyelinating conditions has been previously investigated (Komoly et al., 1992; Mason et al., 2000a,b, 2003, Yao et al., 1995; Ye et al., 2002), yet a role for IGF-1 protection in the treatment of GLD has not been demonstrated. A number of studies have shown that IGF-1 accelerates the differentiation of OL precursors into mature OL, and it prevents apoptotic cell death in cells having the IGF-1 receptor (IGF-1R) (Dubois-Dalcq and Murray, 2000; Mason et al., 2003; Mozell and McMorris, 1988; Zumkeller, 1997). IGF-1R-containing cells are widely present in the brain, and they play an important role in the growth, development and survival of the nervous system.
New twist on neuronal insulin receptor signaling in health, disease, and therapeutics
2005, Journal of Pharmacological SciencesPrimary central white matter hypoplasia of the neocortex
2005, Pediatric Neurology