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Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension

Nature Genetics volume 1, pages 72–75 (1992)Cite this article

Abstract

The angiotensin converting enzyme (ACE) is a key component of the renin angiotensin system that contributes to the regulation of blood pressure (BP). Recent demonstration of linkage between the ACE locus and elevated BP in a rat model of hypertension has further emphasized ACE as a candidate gene in human hypertension1,2,3. We report the localization of the ACE gene on the genetic map of chromosome 17, and identify an extremely polymorphic marker at the human growth hormone (hGH) locus which shows no recombination with ACE. We have found no evidence to support linkage between the ACE locus and hypertension, which suggests that mutations at the ACE locus do not commonly contribute to the pathogenesis of hypertension in our test population.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Human Genetics, University of Utah, Health Sciences Center, Salt Lake City, Utah, 84112, USA

    Xavier Jeunemaitre, Richard P. Lifton & Jean-Marc Lalouel

  2. Endocrine–Hypertension Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Richard P. Lifton

  3. Cardiovascular Genetics Research Clinic, University of Utah, Salt Lake City, Utah, 84112, USA

    Steven C. Hunt & Roger R. Williams

Authors
  1. Xavier Jeunemaitre
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  2. Richard P. Lifton
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  4. Roger R. Williams
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  5. Jean-Marc Lalouel
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Jeunemaitre, X., Lifton, R., Hunt, S. et al. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet 1, 72–75 (1992). https://doi.org/10.1038/ng0492-72

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