Abstract
From chromosomal region 17q21.3, where a tumour suppressor gene(s) for breast and ovarian cancers is thought to be present, we have isolated a novel gene from a cosmid clone that revealed somatic rearrangements in two breast cancers. The gene (MDC) encodes a 524–amino acid metalloprotease–like, disintegrin–like and cysteine–rich protein with sequence similarity to members of the snake–venom metalloprotease/disintegrin family and guinea–pig sperm–surface protein PH–30. These proteins have been implicated in cell–cell or cell–extracellular matrix interactions. Rearrangements in both tumours involve multiple exons and disrupt the coding region of the new MDC.
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Emi, M., Katagiri, T., Harada, Y. et al. A novel metalloprotease/disintegrin–like gene at 17q21.3 is somatically rearranged in two primary breast cancers. Nat Genet 5, 151–157 (1993). https://doi.org/10.1038/ng1093-151
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DOI: https://doi.org/10.1038/ng1093-151
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