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Strong indication for a breast cancer susceptibility gene on chromosome 8p12-p22: linkage analysis in German breast cancer families

Oncogene volume 14, pages 741–743 (1997)Cite this article

Abstract

Chromosomal losses involving the short arm of chromosome 8 are frequent in a variety of tumor types, including breast cancer, suggesting the presence of one or more tumor suppressor genes in this region. Previous linkage analysis and studies of loss of heterozygosity (LOH) have suggested the presence of a putative third breast cancer susceptibility gene around D8S505 at 8p12-p22. We have performed linkage analysis in two German breast cancer families, showing negative lod scores with 17q and 13q markers, using seven adjacent microsatellite markers from 8p12-p22. Incorporating LOH data from tumors of the affected family members a maximum cumulative three-point lod score of 3.30 at [circle with M in middle]=0.00 was obtained with D8S137 and D8S131. Our findings considerably strengthen the evidence for a third breast cancer susceptibility locus (BRCA3) mapping to the short arm of human chromosome 8.

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Authors and Affiliations

  1. Department of Tumor Genetics, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Robert Roessle Strasse 10, Berlin, 13122, Germany

    Susanne Seitz, Erhard Bender, Anita Nothnagel, Konrad Kölble & Siegfried Scherneck

  2. Department of Bioinformatics, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Robert Roessle Strasse 10, Berlin, 13122, Germany

    Klaus Rohde

  3. Pathology Department, Charité, Humboldt University of Berlin, Schumannstraße 20-21, Berlin, 10117, Germany

    Konrad Kölble

  4. Department of Surgical Oncology, Robert Roessle Clinic, Humboldt University of Berlin, Robert-Roessle-Strasse 10, Berlin, 13122, Germany

    Peter M Schlag

Authors
  1. Susanne Seitz
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  2. Klaus Rohde
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  3. Erhard Bender
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  4. Anita Nothnagel
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  5. Konrad Kölble
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  6. Peter M Schlag
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  7. Siegfried Scherneck
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Seitz, S., Rohde, K., Bender, E. et al. Strong indication for a breast cancer susceptibility gene on chromosome 8p12-p22: linkage analysis in German breast cancer families. Oncogene 14, 741–743 (1997). https://doi.org/10.1038/sj.onc.1200881

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  • DOI: https://doi.org/10.1038/sj.onc.1200881

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