Abstract
We have previously shown that inactivation of mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a common early event in both human liver and breast carcinogenesis. The M6p/Igf2r is imprinted in mice while expression is biallelic in most humans. In this investigation the M6p/Igf2r gene is shown to also be imprinted in the liver of Fischer 344, Lewis and Brown Norway rats. In addition, we have identified mutations in the expressed allele of the M6p/Igf2r in 40% of diethylnitrosamine-initiated rat liver tumors. These results provide further evidence that the M6P/IGF2R functions as a liver tumor suppressor gene. They also suggest that mice and rats would be more sensitive than humans to those hepatocarcinogens in which the M6p/Igf2r is mechanistically involved in transformation since one rather than two alleles would need to be inactivated.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mills, J., Falls, J., De Souza, A. et al. Imprinted M6p/Igf2 receptor is mutated in rat liver tumors. Oncogene 16, 2797–2802 (1998). https://doi.org/10.1038/sj.onc.1201801
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1201801
Keywords
This article is cited by
-
Imprinted gene expression in hybrids: perturbed mechanisms and evolutionary implications
Heredity (2014)
-
Mannose-6-phosphate/Insulin-like Growth Factor II Receptor Expression and Tumor Development
Bioscience Reports (2006)
-
Decreased expression of the mannose 6- phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells
BMC Cancer (2002)
-
M6P/IGF2R is mutated in squamous cell carcinoma of the lung
Oncogene (2000)