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References
Adachi M, Roussel MF, Havenith K and Sherr CJ. . 1997 Blood 90: 126–137.
Arap W, Knudsen ES, Wang JYJ, Cavenee WK and Huang H-JS. . 1997 Oncogene 14: 603–609.
Bates S, Phillips AC, Clarke P, Stott F, Peters G, Ludwig RL and Vousden KH. . 1998 Nature 395: 124–125.
Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ, Serrano M, Brenner SL, Blundell TL and Laue ED. . 1998 Nature 395: 244–250.
Chan FKM, Zhang J, Chen L, Shapiro DN and Winoto A. . 1995 Mol. Cell. Biol. 15: 2682–2688.
De Stanchina E, McCurrach ME, Zindy F, Shieh S-Y, Ferbeyre G, Samuelson AV, Prives C, Roussel MF, Sherr CJ and Lowe SW. . 1998 Genes Dev. 12: 2434–2442.
Diehl JA, Zindy F and Sherr CJ. . 1997 Genes Dev. 11: 957–972.
Drexler HG. . 1998 Leukemia 12: 845–859.
Dyson N. . 1998 Genes Dev. 12: 2245–2262.
El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer E, Kinzler KW and Vogelstein B. . 1993 Cell 75: 817–825.
Ewen ME. . 1994 Cancer Metastasis Rev. 13: 45–66.
Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai L-H, Broudy V, Perlmutter RM, Kaushansky K and Roberts JM. . 1996 Cell 85: 733–744.
Fitzgerald MG, Harkin DP, Silva-Arrieta S, MacDonald DJ, Lucchina LC, Unsal H, O'Neill E, Koh J, Finkelstein DM, Isselbacher KJ, Sober AJ and Haber DA. . 1996 Proc. Natl. Acad. Sci. USA 93: 8541–8545.
Franklin DS, Godfrey VL, Lee H, Kovalev GI, Schoonhaven R, Chen-Kiang S, Su L and Xiong Y. . 1998 Genes Dev. 12: 2899–2911.
Franklin DS and Xiong Y. . 1996 Mol. Biol. Cell 7: 1587–1599.
Gruis NA, van der Velden PA, Sandkuijl LA, Prins DE, Weaver-Feldhaus J, Kamb A, Bergman W and Frants R. . 1995 Nature Genet. 10: 351–353.
Guan K-L, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG and Xiong Y. . 1994 Genes Dev. 8: 2939–2952.
Hall M and Peters G. . 1996 Adv. Cancer Res. 68: 67–108.
Hannon GJ and Beach D. . 1994 Nature 371: 257–261.
Hara E, Smith R, Parry D, Tahara H, Stone S and Peters G. . 1996 Mol. Cell. Biol. 16: 859–867.
Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ. . 1993 Cell 75: 805–816.
Harper JW and Elledge SJ. . 1996 Curr. Opin. Genet. Dev. 6: 56–64.
Hirai H, Roussel MF, Kato J, Ashmun RA and Sherr CJ. . 1995 Mol. Cell. Biol. 15: 2672–2681.
Hirama T and Koeffler HP. . 1995 Blood 86: 841–854.
Hussussian CJ, Struewing JP, Goldstein AM, Higgans PAT, Ally DS, Sheahan MD, Clark WH, Tucker MA and Dracopoli NC. . 1994 Nature Genet. 8: 15–21.
Kamb A, Shattuck-Eidens D, Eeles R, Liu Q, Gruis NA, Ding W, Hussey C, Tran T, Miki Y, Weaver-Feldhaus J, McClure M, Aitken JF, Anderson DE, Bergman W, Frants R, Goldgar DE, Green A, MacLennan R, Martin NG, Meyer LJ, Youl P, Zone JJ, Skolnick MH and Cannon-Albright LA. . 1994 Nature Genet. 8: 22–26.
Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF and Sherr CJ. . 1998 Proc. Natl. Acad. Sci. USA 95: 8292–8297.
Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G and Sherr CJ. . 1997 Cell 91: 649–659.
Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, Khanam D, Hayday AC, Frohman LA and Koff A. . 1996 Cell 85: 721–732.
Koh J, Enders GH, Dynlacht BD and Harlow E. . 1995 Nature 375: 506–510.
Lamphere L, Fiore F, Xu X, Brizuela L, Keezer S, Sardet C, Draetta GF and Gyuris J. . 1997 Oncogene 14: 1999–2004.
Li J, Byeon I-JL, Ericson K, Poi M-J, O'Maille P, Selby T and Tsai M-D. . 1999 Biochemistry 38: 2930–2940.
Lukas J, Parry D, Aagaard L, Mann DJ, Barkkova J, Strauss M, Peters G and Bartek J. . 1995 Nature 375: 503–506.
Mahony D, Parry DA and Lees E. . 1998 Oncogene 13: 603–611.
McConnell BB, Gregory FJ, Stott FJ, Hara E and Peters G. . 1999 Mol. Cell. Biol. 19: 1981–1989.
Medema RH, Herrara RE, Lam F and Weinberg RA. . 1995 Proc. Natl. Acad. Sci. USA 92: 6289–6293.
Miller CW, Yeon C, Aslo A, Mendoza S, Aytac U and Koeffler HP. . 1997 Oncogene 15: 231–235.
Morse L, Chen D, Franklin D, Xiong Y and Chen-Kiang S. . 1997 Immunity 6: 47–56.
Nakayama K-I and Nakayama K. . 1998 BioEssays 20: 1020–1029.
Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, Horii I and Loh DY. . 1996 Cell 85: 707–720.
Nevins JR. . 1998 Cell Growth & Differ. 9: 585–593.
Noh SJ, Li Y, Xiong Y and Guan K-L. . 1999 Cancer Res. 59: 558–564.
Okuda T, Shurtleff SA, Valentine MB, Raimondi SC, Head DR, Behm F, Curcio-Brint AM, Liu Q, Pui CH, Sherr CJ, Beach D, Look AT and Downing JR. . 1995 Blood 85: 2321–2330.
Pavletich NP. . 1999 J. Mol. Biol. 287: 821–828.
Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee H-W, Cordon-Cardo C and DePinho R. . 1998 Cell 92: 713–723.
Quelle DE, Cheng M, Ashmun RA and Sherr CJ. . 1997 Proc. Natl. Acad. Sci. USA 94: 3436–3440.
Quelle DE, Zindy F, Ashmun RA and Sherr CJ. . 1995 Cell 83: 993–1000.
Ranade K, Hussussian CJ, Sikorski RS, Varmus HE, Goldstein AM, Tucker MA, Serrano M, Hannon GJ, Beach D and Dracopoli NC. . 1995 Nature Genetics 10: 114–116.
Ruas M and Peters G. . 1998 BBA Reviews in Cancer 1378: F115–F177.
Russo AA, Tong L, Lee J-O, Jeffrey PD and Pavletich NP. . 1998 Nature 395: 237–243.
Schmidt EE, Ichimura K, Reifenberger G and Collins VP. . 1994 Cancer Res. 54: 6321–6324.
Serrano M, Hannon GJ and Beach D. . 1993 Nature 366: 704–707.
Serrano M, Lee H-W, Chin L, Cordon-Cardo C, Beach D and DePinho RA. . 1996 Cell 85: 27–37.
Sharpless NE and DePinho RA. . 1999 Current Opinion Genet. Dev. 9: 22–30.
Sherr CJ. . 1994 Trends in Cell Biology 4: 15–18.
Sherr CJ. . 1998 Genes Dev. 12: 2984–2991.
Sherr CJ and Roberts JM. . 1995 Genes Dev. 9: 1149–1163.
Sherr CJ and Roberts JM. . 1999 Genes Dev. In press.
Stepanova L, Leng X, Parker SB and Harper JW. . 1996 Genes Dev. 10: 1491–1502.
Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G and Kamb A. . 1995 Cancer Res. 55: 2988–2994.
Tao W and Levine AJ. . 1999 Proc. Natl. Acad. Sci. USA 96: 6937–6941.
Venkataramani R, Swaminathan K and Marmorstein R. . 1998 Nature Structural Biology 5: 74–81.
Washimi O, Nagatake M, Osada H, Ueda R, Koshikawa T, Seki T, Takahashi T and Takehashi T. . 1995 Cancer Res. 55: 514–517.
Weber JD, Taylor LJ, Roussel MF, Sherr CJ and Bar-Sagi D. . 1999 Nat. Cell. Biol. 1: 1–7.
Weinberg RA. . 1995 Cell 81: 323–330.
Wölfel T, Hauer M, Schneider J, Serrano M, Wölfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Buschenfelde K-H and Beach D. . 1995 Science 269: 1281–1284.
Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D. . 1993 Nature 366: 701–704.
Yang R, Gombart AF, Serrano M and Koeffler HP. . 1995 Cancer Res. 55: 2503–2506.
Zhang Y, Xiong Y and Yarbrough WG. . 1998 Cell 92: 725–734.
Zindy F, Eischen CM, Randle D, Kamijo T, Cleveland JL, Sherr CJ and Roussel MF. . 1998 Genes Dev. 12: 2424–2433.
Zindy F, Quelle DE, Roussel MF and Sherr CJ. . 1997a Oncogene 15: 203–211.
Zindy F, Soares H, Herzog K-H, Morgan J, Sherr CJ and Roussel MF. . 1997b Cell Growth & Differ. 8: 1139–1150.
Acknowledgements
I am deeply indebted to John Cleveland, Veronika Sexl and Frederique Zindy for their criticisms and comments of this review and Julia-Cay Jones for scientific editing, Charles Sherr for his continuous support and the members of the Roussel/Sherr laboratories for helpful discussions. MF Roussel is funded by NIH grant PO1 CA-71907, the Cancer Core CA-21765, and the American Lebanese Syrian Associated Charities (ALSAC) of St Jude Children's Research Hospital.
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Roussel, M. The INK4 family of cell cycle inhibitors in cancer. Oncogene 18, 5311–5317 (1999). https://doi.org/10.1038/sj.onc.1202998
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