Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Paper
  • Published:

Dual regulation of proliferation and apoptosis: c-myc in bitransgenic murine mammary tumor models

Oncogene volume 19, pages 1065–1071 (2000)Cite this article

Abstract

Recent progress in the study of c-Myc has convincingly demonstrated that it possesses a dual role in regulating both proliferation and apoptosis; however, the manner in which c-Myc influences these cellular response pathways remains incompletely characterized. Deregulation of c-Myc expression, via many mechanisms, is a common feature of multiple cancers and is an especially prominent feature of many breast cancers. Of significant interest to those who study mammary gland development and neoplasia is the unresolved nature and contribution of apoptosis to breast tumorigenesis. Recently, the use of transgenic mice and gene-knockout mice has allowed investigators to evaluate the pathological mechanisms by which different genes influence tumor development and progression. In this review, we address two distinct c-myc-containing bitransgenic murine mammary tumor models and discuss the contribution and possible future directions for resolution of cancer-relevant molecular pathways influenced by c-Myc.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  • Amundadottir LT, Johnson MD, Merlino G, Smith GH and Dickson RB. . 1995 Cell Growth Diff. 6: 737–748.

  • Amundadottir LT, Merlino G and Dickson RB. . 1996a Breast Cancer Res. Treat. 39: 119–135.

  • Amundadottir LT, Nass SJ, Berchem GJ, Johnson MD and Dickson RB. . 1996b Oncogene 13: 757–765.

  • Amundadottir LT and Leder P. . 1998 Oncogene 16: 737–746.

  • Arteaga CL, Hanauske AR, Clark GM, Osborne K, Hazarika P, Pardue RL, Tio F and Von Hoff DD. . 1988 Cancer Res. 48: 5023–5028.

  • Bates SE, Davidson NE, Valverius EM, Freter CE, Dickson RB, Tam JP, Kudlow JE, Lippman ME and Salomon DS. . 1988 Mol. Endocrinol. 2: 543–555.

  • Bates SE, Valverius EM, Ennis BW, Bronzert DA, Sheridan JP, Stampfer MR, Mendelsohn J, Lippman ME and Dickson RB. . 1990 Endocrinology 126: 596–607.

  • Brinster RL. . 1972 In: Growth, Nutrition and Metabolism of Cells in Culture. Rothblat G and Cristafalo V (eds). Academic: New York vol 2: pp. 251–286.

    Book  Google Scholar 

  • Brinster RL, Ritchie KA, Hammer RE, O'Brien RL, Arp B and Storb U. . 1983 Nature 306: 332–336.

  • Canman CE and Kastan MB. . 1997 Adv. Pharmacol. 41: 429–460.

  • Dahiya R and Deng G. . 1998 Breast Cancer Res. Treat. 52: 185–200.

  • Dang CV. . 1999 Mol. Cell. Biol. 19: 1–11.

  • De Luca A, Casamassimi A, Selvam MP, Losito S, Ciardiello F, Agrawal S, Salomon DS and Normanno N. . 1999 Int. J. Cancer 80: 589–594.

  • Deming SL, Nass SJ, Dickson RB and Trock BJ. . 1999 Abstract No. 1358, Proceedings of the Annual Meeting of the AACR Philadelphia, PA.

    Google Scholar 

  • Derynck R, Goeddel DV, Ullrich A, Gutterman JU, Williams RD, Bringman TS and Berger WH. . 1987 Cancer Res. 47: 707–712.

  • De Stanchina E, McCurrach ME, Zindy F, Shieh S-Y, Ferbeyre G, Samuelson AV, Prives C, Roussel MF, Sherr CJ and Lowe SW. . 1998 Genes Dev. 12: 2434–2442.

  • Dickson RB and Lippman ME. . 1995 Endocrine Rev. 16: 559–589.

  • Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS and Bradley A. . 1992 Nature 356: 215–221.

  • Donehower LA and Bradley A. . 1993 Biochim. Biophys. Acta 1155: 181–205.

  • Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D and Varmus HE. . 1995 Genes Dev. 9: 882–895.

  • Edwards PAW, Ward JL and Bradbury JM. . 1988 Oncogene 2: 407–412.

  • Eeles RA, Bartkova J, Lane DP and Bartek J. . 1993 Cancer Surv. 18: 57–75.

  • El-Deiry WS. . 1998 Sem. Cancer Biol. 8: 345–357.

  • Elson A, Deng C, Campos-Torres J, Donehower LA and Leder P. . 1995 Oncogene 11: 181–190.

  • Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock DC. . 1992 Cell 69: 119–128.

  • Evan GI and Littlewood TD. . 1993 Curr. Opin. Genet. Dev. 3: 44–49.

  • Evan GI and Littlewood TD. . 1998 Science 281: 1317–1322.

  • Facchini LM and Penn LZ. . 1998 FASEB J. 12: 633–651.

  • Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA and Ruddle FH. . 1980 Proc. Natl. Acad. Sci. USA 77: 7380–7384.

  • Harrington EA, Bennett MR, Fanidi A and Evan GI. . 1994 EMBO J. 13: 3286–3295.

  • Harris AL and Nicholson S. . 1988 In Breast Cancer: Cellular and Molecular Biology. Lippman ME and Dickson RB. (eds).. Boston: Kluwer Press pp. 93–118.

    Book  Google Scholar 

  • Harvey M, McArthur MJ, Montgomery CA, Butel JS, Bradley A and Donehower LA. . 1993 Nature Genet. 5: 225–229.

  • Jaenisch R. . 1976 Proc. Natl. Acad. Sci. USA 73: 1260–1264.

  • Jäger R, Herzer U, Schenkel J and Weiher H. . 1997 Oncogene 15: 1787–1795.

  • Jerry DJ, Kuperwasser C, Downing SR, Pinkas J, He C, Dickinson E, Marconi S and Naber SP. . 1998 Oncogene 17: 2305–2312.

  • Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH and Merlino GT. . 1990 Cell 61: 1137–1146.

  • Jones JM, Attardi L, Godley LA, Laucirica R, Medina D, Jacks T, Varmus HE and Donehower LA. . 1997 Cell Growth Diff. 8: 829–838.

  • Leder A, Pattengale PK, Kuo A, Stewart TA and Leder P. . 1986 Cell 45: 485–495.

  • Lee LW, Raymond VW, Tsao MS, Lee DC, Earp HS and Grisham JW. . 1991 Cancer Res. 51: 5238–5244.

  • Li B, Murphy KL, Laucirica R, Kittrell F, Medina D and Rosen JM. . 1998 Oncogene 16: 997–1007.

  • Li M, Hu J, Heermeier K, Hennighausen L and Furth PA. . 1996 Cell Growth Diff. 7: 13–20.

  • Liao DJ, Natarajan G, Deming SL, Jamerson MH, Johnson M, Chepko G and Dickson RB. . 2000 Oncogene in press.

  • Liscia DS, Merlo G, Ciardiello F, Kim N, Smith GH, Callahan RH and Salomon DS. . 1990 Dev. Biol. 140: 123–131.

  • Liyanage M, Coleman A, du Manoir S, Veldman T, McCormack S, Dickson RB, Barlow C, Wynshaw-Boris A, Janz S, Wienberg J, Ferguson-Smith MA, Schröck E and Ried T. . 1996 Nature Genet. 14: 312–315.

  • Lozano G and Liu G. . 1998 Sem. Cancer Biol. 8: 337–344.

  • Martinez-Lacaci I, Bianco C, DeSantis M and Salomon DS. . 1999 In: Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics, Bowcock AM, (ed.). Humana Press: Totowa NJ vol 1: pp. 31–57.

    Google Scholar 

  • Matsui Y, Halter SA, Holt JT, Hogan BLM and Coffey RJ. . 1990 Cell 61: 1147–1155.

  • McCormack SJ, Weaver Z, Deming S, Natarajan G, Torri J, Johnson MD, Liyanage M, Ried T and Dickson RB. . 1998 Oncogene 16: 2755–2766.

  • McGeady ML, Kerby S, Shankar V, Ciardiello F, Salomon DS and Seidman M. . 1989 Oncogene 4: 1375–1382.

  • Merlo GR, Basolo F, Fiore L, Duboc L and Hynes NE. . 1995 J. Cell. Biol. 128: 1185–1196.

  • Miyashita T and Reed JC. . 1995 Cell 80: 293–299.

  • Nass SJ, Li M, Amundadottir LT, Furth PA and Dickson RB. . 1996 Biochem. Biophys. Res. Comm. 227: 248–256.

  • Nass SJ and Dickson RB. . 1997 Breast Cancer Res. Treat. 44: 1–22.

  • Nass SJ and Dickson RB. . 1998 Clin. Cancer Res. 4: 1813–1822.

  • Packham G and Cleveland JL. . 1995 Biochim. Biophys. Acta 1242: 11–28.

  • Purdie CA, Harrison DJ, Peter A, Dobbie L, White S, Howie SEM, Salter DM, Bird CC, Wyllie AH, Hooper ML and Clarke AR. . 1994 Oncogene 9: 603–609.

  • Salomon DS, Perroteau I, Kidwell WR, Tam J and Derynck R. . 1987 J. Cell. Physiol. 130: 397–409.

  • Sandgren EP, Luetteke NC, Palmiter RD, Brinster RL and Lee DC. . 1990 Cell 61: 1121–1135.

  • Sandgren EP, Schroeder JA, Qui TH, Palmiter RD, Brinster RL and Lee DC. . 1995 Cancer Res. 55: 3915–3927.

  • Santoni-Rugiu E, Jensen MR and Thorgeirsson SS. . 1998 Cancer Res. 58: 123–134.

  • Schoenenberger CA, Andres AC, Groner B, van der Valk M, LeMeur M and Gerlinger P. . 1988 EMBO J. 7: 169–175.

  • Shankar V, Ciardiello F, Kim N, Derynck R, Liscia DS, Merlo G, Langton BC, Sheer D, Callahan R, Bassin RH, Lippman ME, Hynes N and Salomon DS. . 1989 Mol. Carcinogen. 2: 1–11.

  • Sherr CJ. . 1998 Genes Dev. 12: 2984–2991.

  • Siegel PM and Muller WJ. . 1998 In: Hormones and Growth Factors in Development and Neoplasia. Dickson RB and Salomon DS. (eds).. Wiley-Liss: New York pp. 397–420.

    Google Scholar 

  • Sinn E, Muller W, Pattengale P, Tepler I, Wallace R and Leder P. . 1987 Cell 49: 465–475.

  • Snedeker SM, Brown CF and DiAugustine RP. . 1991 Proc. Natl. Acad. Sci. USA 88: 276–280.

  • Stewart TA, Pattengale PK and Leder P. . 1984 Cell 38: 627–637.

  • Strange R, Li F, Saurer S, Burkhardt A and Friis RR. . 1992 Development 115: 49–58.

  • Telang NT, Osborne MP, Sweterlitsch LA and Narayanan R. . 1990 Cell Regulation 1: 863–872.

  • Travers MT, Barrett-Lee PJ, Berger U, Luqmani YA, Gazet JC, Powler TJ and Coombes RC. . 1988 Br. Med. J. 296: 1621–1624.

  • Valverius EM, Bates S, Stampfer MR, Clark R, McCormick F, Salomon DS, Lippman ME and Dickson RB. . 1989 Mol. Endocrinol. 3: 203–214.

  • Valverius EM, Ciardiello F, Heldin NE, Blondel B, Merlino G, Smith GH, Stampfer MR, Lippman ME, Dickson RB and Salomon DS. . 1990 J. Cell. Physiol. 145: 207–216.

  • Wang JK, Johnson MD, Rosfjord EC, Jamerson MH and Dickson RB. . 1999 Abstract No. 1093 Proceedings of the Annual Meeting of the AACR Philadelphia, PA.

    Google Scholar 

  • Weaver ZA, McCormack SJ, Liyanage M, du Manoir S, Coleman A, Schröck E, Dickson RB and Ried T. . 1999 Genes Chrom. Cancer 25: 251–260.

  • Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ and Roussel MF. . 1998 Genes Dev. 12: 2424–2433.

Download references

Acknowledgements

This work was supported by NIH Grants 1R01AG1496 and 1R01CA72460 to RB Dickson and a Department of Defense Grant DAMD-17-97-1-7110 to MH Jamerson. We thank Sandra L Deming and Dr Danica Ramljak for valuable discussion and critical reading of the manuscript.

Author information

Authors and Affiliations

  1. The Lombardi Cancer Center, Georgetown University Medical Center, Georgetown University, Washington, 20007, DC, USA

    M Hunter Jamerson, Michael D Johnson & Robert B Dickson

Authors
  1. M Hunter Jamerson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael D Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Robert B Dickson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jamerson, M., Johnson, M. & Dickson, R. Dual regulation of proliferation and apoptosis: c-myc in bitransgenic murine mammary tumor models. Oncogene 19, 1065–1071 (2000). https://doi.org/10.1038/sj.onc.1203268

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1203268

Keywords

This article is cited by

Search

Advanced search

Quick links