Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Paper
  • Published:

Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients

Oncogene volume 19, pages 3733–3738 (2000)Cite this article

Abstract

To discriminate among the chromosomal abnormalities associated with the etiology of hepatocellular carcinoma (HCC), we performed a comparative genomic hybridization (CGH) analysis on 34 HCCs resected on non-cirrhotic livers from patients serologically negative for both hepatitis B (HBV) and C (HCV) viruses. The results were compared to those of a previous analysis of 50 HCCs selected on the basis of their positivity for HBV infection. The majority of the abnormalities found in the HBV positive cases (losses of chromosome arms 1p, 8p, 6q, 13q and 14q and gains of 1q, 8q, 6p and 17q) were similarly detected in the virus negative specimens. In contrast, a significant decrease (40% on average) was observed for losses at 4q, 16q and 17p in non-viral HCC samples, suggesting that these abnormalities are tightly associated with HBV infection. Thus, in addition to a common pathway towards malignancy, a subset of alterations may preferentially contribute to virus-induced carcinogenesis. In a parallel CGH study of 10 fibrolamellar carcinomas, a rare subtype of HCC, we found in six out of the seven informative cases, gains of chromosome arm 1q. This region, which is also preferentially amplified in non fibrolamellar tumors (58%), may contain an essential proto-oncogene commonly implicated in liver carcinogenesis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  • Arribas R, Risques RA, Gonzalez-Garcia I, Masramon L, Aiza G, Ribas M, Capella G and Peinador MA. . 1999 Lab. Invest. 79: 111–122.

  • Bentz M, Plesch A, Stilgenbauer S, Dohner H and Lichter P. . 1998 Genes Chrom. Cancer 21: 172–175.

  • Boige V, Laurent-Puig P, Fouchet P, Flejou JF, Monges G, Bedossa P, Bioulac-Sage P, Capron F, Schmitz A, Olschwang S and Thomas G. . 1997 Cancer Res. 57: 1986–1990.

  • Craig J, Peters R, Edmondson H and Omata M. . 1980 Cancer 46: 372–379.

  • Duff EK and Clarke AR. . 1998 Br. J. Cancer 78: 1615–1619.

  • Edmonson H and Steiner PE. . 1954 Cancer 7: 462–503.

  • El-Rifai W, Larramendy M, Bjorkqvist A, Hemmer S and Knuutila S. . 1997 Lab. Invest. 77: 699–700.

  • El-Rifai W, Kamel D, Larramendy ML, Shoman S, Gad Y, Baithun S, Al-Awady M, Eissa S, Khaleid H, Soloneski S, Sheaff M and Knuutila S. . 2000 Am. J. Pathol. 156: 871–878.

  • Ishak K, Batista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween R, Phillips M, Portmann B, Poulsen H, Scheuer P, Schmid M and Thaler H. . 1995 J. Hepatol. 22: 696–699.

  • Ishwad CS, Shuster M, Bockmuhl U, Thakker N, Shah P, Toomes C, Dixon M, Ferrell RE and Gollin SM. . 1999 Int. J. Cancer 80: 25–31.

  • Jernvall P, Makinen MJ, Karttunen TJ, Makela J and Vihko P. . 1999 Br. J. Cancer 79: 903–908.

  • Kallioniemi OP, Kallioniemi A, Piper J, Isola J, Waldman FM, Gray JW and Pinkel D. . 1994 Genes Chrom. Cancer 10: 231–243.

  • Kato A, Kurokawa F, Okita K and Murakami T. . 1998 Dig. Dis. Sci. 43: 1–7.

  • Konishi M, Kikuchi-Yanoshita R, Tanaka K, Sato C, Tsuruta K, Maeda Y, Koike M, Tanaka S, Nakamura Y and Hattori N. . 1993 Jpn. J. Cancer 84: 893–899.

  • Kuroki T, Fujiwara Y, Tsuchiya E, Nakamori S, Imaoka S, Kanematsu T and Nakamura Y. . 1995 Genes Chrom. Cancer 13: 163–167.

  • Kusano N, Shiraishi K, Kubo K, Oga A, Okita K and Sasakil K. . 1999 Hepatology 29: 1858–1862.

  • Leé D, Koch W, Yoo G, Lango M, Reed A, Califano J, Brennan J, Westra W, Zahurak M and Sidransky D. . 1997 Clin. Cancer Res. 3: 501–505.

  • Lerebours F, Olschwang S, Schmitz A, Fouchet P, Laurent-Puig P, Boman F, Flejou J, Monges G, Paraf F, Bedossa P, Sabourin JC, Salmon RJ, Parc R and Thomas G. . 1999 Genes Chrom. Cancer 2: 145–153.

  • Marchio A, Meddeb M, Pineau P, Danglot G, Tiollais P, Bernheim A and Dejean A. . 1997 Genes Chrom. Cancer 18: 59–65.

  • Mertens F, Johannson B and Mitelman F. . 1994 Genes, Chrom. Cancer 10: 221–230.

  • Mertens F, Johansson B, Höglund M and Mitelman F. . 1997 Cancer Res. 57: 2765–2780.

  • Nagai H, Pineau P, Tiollais P, Buendia MA and Dejean A. . 1997 Oncogene 14: 2927–2933.

  • Orsatti G, Hytiroglou P, Thung SN, Ishak KG and Paronetto F. . 1997 Liver 17: 152–156.

  • Pearlstein RP, Benninger MS, Carey TE, Zarbo RJ, Torres FX, Rybicki BA and Dyke DL. . 1998 Genes Chrom. Cancer 21: 333–339.

  • Pineau P, Nagai H, Prigent S, Wei Y, Gyapay G, Weissenbach J, Tiollais P, Buendia MA and Dejean A. . 1999 Oncogene 18: 3127–3134.

  • Puisieux A and Ozturk M. . 1997 Pathol. Biol. (Paris) 45: 864–870.

  • Radford D, Phillips N, Fair K, Ritter J, Holt M and Donis-Keller H. . 1995 Cancer Res. 55: 5180–5183.

  • Ragnarsson G, Eiriksdottir G, Johannsdottir J, Jonasson J, Egilsson V and Ingvarsson S. . 1999 Br. J. Cancer 79: 1468–1474.

  • Rumpel CA, Powell SM and Moskaluk CA. . 1999 Am. J. Pathol. 154: 1329–1334.

  • Sakakura C, Hagiwara A, Taniguchi H, Yamaguchi T, Yamagishi H, Takahashi T, Koyama K, Nakamura Y, Abe T and Inazawa J. . 1999 Br. J. Cancer 80: 2034–2039.

  • Sambrook J, Fritsch E and Maniatis T. . 1989 Molecular cloning: A Laboratory Manual, 1st ed. Cold Spring Harbor. NY: Cold Spring Harbor Laboratory Press.

  • Schullerus D, von Knobloch R, Chudek J, Herbers J and Kovacs G. . 1999 Int. J. Cancer 80: 22–24.

  • Schwerdtle RF, Winterpacht A, Storkel S, Brenner W, Hohenfellner R, Zabel B, Huber C and Decker HJ. . 1997 Cancer Res. 57: 5009–5012.

  • Tran Y, Benbatoul K, Gorse G, Rempel S, Futreal A, Green M and Newsham I. . 1998 Oncogene 17: 3499–3505.

  • Tumilowicz J, Nichols W, Cholon J and Greene A. . 1970 Cancer Res. 30: 2110–2118.

  • Viegas-Péquignot E and Dutrillaux B. . 1978 Ann. Génèt. (Paris) 21: 122–124.

  • Wong N, Lai P, Lee SW, Fan S, Pang E, Liew CT, Sheng Z, Lau JW and Johnson PJ. . 1999 Am. J. Pathol. 154: 37–43.

  • Wright K, Wilson PJ, Kerr J, Do K, Hurst T, Khoo SK, Ward B and Chenevix-Trench G. . 1998 Oncogene 17: 1185–1188.

  • Zhang X, Xu HJ, Murakami Y, Sachse R, Yashima K, Hirohashi S, Hu SX, Benedict WF and Sekiya T. . 1994 Cancer Res. 54: 4177–4182.

Download references

Acknowledgements

We gratefully acknowledge Dr Dominique Higuet for statistical assistance. This work was supported by grants from the Association pour la Recherche sur le Cancer (ARC) and la Ligue Nationale contre le Cancer.

Author information

Authors and Affiliations

  1. Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, France

    Agnès Marchio, Pascal Pineau, Pierre Tiollais & Anne Dejean

  2. Laboratoire de Cytogénétique et Génétique Oncologiques (URA 1967 CNRS), Institut Gustave Roussy, Villejuif, France

    Mounira Meddeb & Alain Bernheim

  3. Laboratoire d'Anatomie Pathologique, Hôpital Beaujon, Clichy, France

    Benoît Terris

Authors
  1. Agnès Marchio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pascal Pineau
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mounira Meddeb
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Benoît Terris
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Pierre Tiollais
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alain Bernheim
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Anne Dejean
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marchio, A., Pineau, P., Meddeb, M. et al. Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients. Oncogene 19, 3733–3738 (2000). https://doi.org/10.1038/sj.onc.1203713

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1203713

Keywords

This article is cited by

Search

Advanced search

Quick links