Regular ArticleOestradiol Stimulates Morphological and Functional Differentiation of Human Villous Cytotrophoblast
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Activation of G protein-coupled estrogen receptor stimulates placental human chorionic gonadotropin expression through PKA-CREB signaling
2023, Molecular and Cellular EndocrinologyTGF-β1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation
2018, Cellular SignallingCitation Excerpt :Therefore, a better understanding of trophoblast cell differentiation will allow us to delineate the events involved in the establishment of pregnancy under normal and pathological conditions. Thus far, several growth factors, hormones and cytokines have been shown to regulate trophoblast differentiation [24–29]. We and others have shown that TGF-β1 induces the differentiation of human trophoblast cells into syncytiotrophoblasts [12,13,16].
Sp1 transcription factor is a modulator of estradiol leptin induction in placental cells
2017, PlacentaCitation Excerpt :Human placenta synthesizes estrogens during pregnancy [23], in association with the cytotrophoblast invasion [24,25]. Moreover, placenta derived estrogen plays an autocrine role in trophoblast differentiation [26,27]. Estrogen receptors (ER) ERα and β proteins have been localized in nuclei of cultured human syncytiotrophoblast cells using immunohistochemistry [27].
Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit
2017, Molecular and Cellular EndocrinologyCitation Excerpt :H295R cells represent the fetal compartment by providing androgen precursors, including 16α-hydroxylated androgens that are converted to estrogens in BeWo cells, which express relatively high levels of placental CYP19 (Hudon Thibeault et al., 2014). Disruption of estrogen synthesis by SSRIs may affect several processes during pregnancy, including remodeling of utero-placental arteries, trophoblast invasion and syncytialization of villous trophoblast (Albrecht et al., 2000; Cronier et al., 1999). Indeed, normal pregnancy is characterized by continuous estrogen secretion increase throughout pregnancy and estriol secretion can be used to assess pregnancy health and fetal well-being (Braunstein et al., 2003).
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