Basic ScienceBasic Principles and Clinical Applications of Biochemical Markers of Bone Metabolism: Biochemical and Technical Aspects
References (181)
- et al.
Human liver plasma membranes contain an enzyme activity that removes membrane anchor from alkaline phosphatase and converts it to a plasma-like form
Clin Biochem
(1994) - et al.
A simple electrophoretic method for separating elevated liver and bone alkaline phosphatase isoenzymes in plasma after neuraminidase treatment
Clin Chim Acta
(1992) - et al.
Quantitation of human intestinal and liver/bone alkaline phosphatase in serum by rocket electroimmunoassay
Analyt Biochem
(1984) - et al.
Clinical usefulness of alkaline phosphatase isoenzyme determinations
Clin Biochem
(1977) - et al.
The vitamin K-dependent synthesis of gamma-carboxyglutamic acid by bone microsomes
J Biol Chem
(1978) - et al.
Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis
Lancet
(1984) - et al.
A one step sandwich enzyme immunoassay for gamma-carboxylated osteocalcin using monoclonal antibodies
J Immunol Methods
(1991) - et al.
Development of a new radioimmunoassay for human osteocalcin: evidence for a midmolecule epitope
Metabolism
(1988) - et al.
Serum bone-Gla-protein compared to bone histomorphometry in endocrine diseases
Bone
(1985) - et al.
Degradation of bone matrix proteins by osteoclast cathepsins
Int J Biochem
(1993)
Stress decreases the serum level of osteocalcin
Bone Miner
Identification and partial characterization of the non-collagenous amino- and carboxy-terminal extension peptides of cartilage procollagen
Biochem Biophys Res Commun
The carboxy-terminal propeptide of type 1 procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones
Metabolism
Assessment of bone remodeling using biochemical indicators of type I collagen synthesis and degradation: relation to calcium kinetics
Bone Miner
Hydroxyproline metabolism by the rat kidney: distribution of renal enzymes of hydroxyproline catabolism and renal conversion of hydroxyproline to glycine and serine
Metabolism
Urinary excretion of hydroxyproline in health and disease
Int Rev Connect Tissue Res
Estimation of whole body bone resorption rate: a comparison of urinary total hydroxyproline excretion with two radioisotopic tracer methods in osteoporosis
Clin Chim Acta
Mechansims Regulating Osteoblast Proliferation and Differentiation
Physiology of Calcium and Phosphate Homeostasis
The human alkaline phosphatases: what we know and what we don't know
Clin Chim Acta
Biochemistry of alkaline phosphatase isoenzymes
CRC Crit Rev Clin Lab Sci
Sugar-chain heterogeneity of human alkaline phosphatases: differences between normal and tumour-associated isoenzymes
Am J Dis Child
Posttranslational heterogeneity of bone alkaline phosphatase in metabolic bone disease
Eur J Clin Chem Clin Biochem
Automated differential isoenzyme analysis. II. The fractionation of serum alkaline phosphatase into liver, intestinal, and other components
Enzymologia
Age and sex distribution of alkaline phosphatase isoenzymes by agarose electrophoresis
Clin Chem
The preparation of monoclonal antibodies which react preferentially with human bone alkaline phosphatase and not liver alkaline phosphatase
Clin Chem Acta
Quantifizierung der alkalischen Knochenphosphatase im Serum mittels Präzipitation und Elektrophorese—Methodenvergleich und Referenzwerte
Klin Lab
Two new methods for separating and quantifying bone and liver alkaline phosphatase isoenzymes in plasma
Clin Chem
Lectin affinity electrophoresis of alkaline phosphatase for the differentiation of bone hepatobiliary disease
Electrophoresis
Alkaline phosphatase isoenzymes resolved by electrophoresis on lectin-containing agarose gel
Clin Chem
Assay of alkaline phosphatase isoenzymes by a convenient precipitation and inhibition methodology
Chem Pharm Bull
Quantification of bone alkaline phosphatase in serum by precipitation with wheat-germ lectin: a simplified method and its clinical plausibility
Clin Chem
Wheat-germ agglutinin method for measuring bone and liver isoenzymes of alkaline phosphatase assessed in post-menopausal osteoporosis
Clin Chem
Wheat-germ lectin affinity electrophoresis for alkaline phosphatase isoforms in children: age-dependent reference ranges and changes in liver and bone disease
Clin Chem
Plasma bone-specific alkaline phosphatase as an indicator of osteoblastic activity
J Bone Joint Surg
Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum
Clin Chem
Analytical and clinical evaluation of a method to quantify bone alkaline phosphatase, a marker of osteoblastic activity
Anticancer Res
Comparison of total and bone-specific alkaline phosphatase in patients with nonskeletal disorders or metabolic bone disease
Clin Chem
Non-invasive evaluation of bone formation: measurements of serum alkaline phosphatase, whole body retention of diphosphonate and serum osteocalcin in metabolic bone disorders and thyroid disease
Scand J Clin Lab Invest
Bone alkaline phosphatase as indicator of bone formation
Clin Chim Acta
Improved method for quantitative determination in serum of alkaline phosphatase of skeletal origin
Clin Chem
Clinical assessment of the electrophoretic separation of alkaline phosphatase isoenzymes
Am J Clin Pathol
Carboxylated calcium-binding proteins and vitamin K
New Engl J Med
Calcium-dependent alpha-helical structure in osteocalcin
Biochemistry
Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone
Physiol Rev
Vitamin K Dependent Proteins of Bone and Cartilage
Vitamin K-Dependent Proteins
Increased bone formation in osteocalcin-deficient mice
Nature
Homologous radioimmunoassay of human osteocalcin
Clin Chem
Region-specific radioimmunoassay for human gamma-carboxyglutamic acid-containing protein (BGP) in blood of normal subjects
Calcif Tissue Int
Cited by (53)
Bone remodeling and calcium homeostasis in patients with spinal cord injury: A review
2011, Metabolism: Clinical and ExperimentalCitation Excerpt :It was noted that OC indicates not only bone formation by reflecting mature osteoblasts activity but also overall bone turnover [23]. These markers are reliable, noninvasive, and relatively cost-efficient for bone turnover assessment [24,25]. In addition, bone markers allow for monitoring minor and acute changes in bone turnover, which is not possible with DXA methods because the detection of BMD changes in this population requires a few months [9,26].
Sintered dicalcium pyrophosphate decreases bone turnover rate in osteoporotic rat: A study on serum biochemical bone turnover markers
2011, Biomedicine and Aging PathologyCitation Excerpt :For this reason, bone turnover markers are applied to demonstrate the biological mechanism of SDCP on bone [19]. Serum ALP, OC and OPN levels were evaluated for bone formation [20]. ALP, an osteoblast-related protein, plays an important role in osteoid formation and mineralization [21].
Reference intervals of biochemical bone turnover markers for Saudi Arabian women: A cross-sectional study
2010, BoneCitation Excerpt :Bone is a dynamic tissue consistently undergoing remodeling through a cycle that includes formation and resorption. Biochemical bone turnover markers (BTMs) are specific bone-derived molecules categorized as bone formation or resorption markers: these markers are present in serum or urine and are reliable, non-invasive, and relatively inexpensive methods for assessing bone turnover [1,2]. Over the past two decades, specific assays of biochemical BTMs have been developed and were used with other parameters in the diagnosis, monitoring and management of metabolic bone diseases including osteoporosis [3].
A new approach for evaluating bone turnover in chronic kidney disease
2010, European Journal of Internal MedicineCitation Excerpt :Currently, there is no useful non-invasive marker of bone resorption available for uremic patients. However, in the general population, breakdown products of bone collagen, specifically the N-terminal telopeptide (NTx) and deoxypyridinoline (DPD) either in the serum or excreted in the urine (and normalized for urine creatinine), can be used as markers of bone resorption [12–14]. NTx and DPD accumulate in the plasma of uremic patients and are not indicative of bone resorption, but are instead the result of decreased renal clearance [15–17].
Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins
2007, BoneCitation Excerpt :Pair-wise contrasts among adjusted means from the ANCOVA were determined at each time point. Four subjects' (2 sets of twins) samples (blood and urine samples from before bed rest and bed rest days 4 and 12) thawed in transit from UCSD to the Johnson Space Center in Houston, but statistical analyses were performed with these samples included in the data set unless there was reason to believe that thawing would have affected measurement of an analyte (for example, osteocalcin rapidly degrades at temperatures greater than 4°C [33]). Whenever the thawing of samples affected the results, the differences between statistical analyses of all samples and analyses of all minus the thawed samples are reported.