Abstract
Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt--Frizzled--LRP5/6 receptor complexes, thus blocking the canonical Wnt--beta-catenin pathway.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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Frizzled Receptors
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Humans
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Intercellular Signaling Peptides and Proteins
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LDL-Receptor Related Proteins
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Low Density Lipoprotein Receptor-Related Protein-5
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Protein Binding
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Proteins / antagonists & inhibitors
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Proteins / metabolism*
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Proteins / physiology
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Proto-Oncogene Proteins / antagonists & inhibitors
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Proto-Oncogene Proteins / metabolism*
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Receptors, LDL / antagonists & inhibitors
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Receptors, LDL / metabolism
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Signal Transduction*
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Wnt Proteins
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Zebrafish Proteins*
Substances
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DKK1 protein, human
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Frizzled Receptors
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Intercellular Signaling Peptides and Proteins
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LDL-Receptor Related Proteins
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LRP5 protein, human
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Low Density Lipoprotein Receptor-Related Protein-5
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Proteins
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Proto-Oncogene Proteins
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Receptors, LDL
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Wnt Proteins
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Zebrafish Proteins
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dkk1b protein, zebrafish