New complexities for BRCA1 and BRCA2

Curr Biol. 2001 Aug 21;11(16):R668-76. doi: 10.1016/s0960-9822(01)00389-x.

Abstract

A large number of diverse functions have been attributed to the BRCA1 and BRCA2 breast cancer susceptibility genes. Here we review recent progress in the field.

Publication types

  • Review

MeSH terms

  • BRCA1 Protein / physiology*
  • BRCA2 Protein / physiology*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • DNA / metabolism
  • DNA Repair
  • DNA-Binding Proteins*
  • Fanconi Anemia / genetics
  • Fanconi Anemia / physiopathology
  • Fanconi Anemia Complementation Group Proteins
  • Female
  • Genes, BRCA1*
  • Genes, BRCA2*
  • Humans
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Protein Structure, Tertiary
  • RNA Helicases / metabolism
  • Transcription, Genetic
  • Tumor Suppressor Proteins*
  • Ubiquitin-Protein Ligases*

Substances

  • BRCA1 Protein
  • BRCA2 Protein
  • Carrier Proteins
  • DNA-Binding Proteins
  • Fanconi Anemia Complementation Group Proteins
  • Nuclear Proteins
  • Tumor Suppressor Proteins
  • DNA
  • BARD1 protein, human
  • Ubiquitin-Protein Ligases
  • BRIP1 protein, human
  • RNA Helicases