Abstract
In this preliminary series, the product of the tumour suppressor gene p53 was detected in 12/15 cases of oral squamous cell carcinoma (SCC) and in two cases of leukoplakia. The tumours either expressed the mutant form of p53 throughout the specimen or contained focal areas of positive cells. p53 expression was commonly observed in tumours obtained from patients who were heavy smokers and drinkers suggesting that alterations in the p53 gene may be one of the sites of genetic damage in this group of patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohol Drinking / genetics
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Alcohol Drinking / metabolism
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Antibodies, Monoclonal
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Carcinoma, Squamous Cell / chemistry*
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / pathology
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Cell Nucleus / chemistry
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Cell Nucleus / ultrastructure
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Cytoplasm / chemistry
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Cytoplasm / ultrastructure
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Epitopes
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Erythroplasia / chemistry*
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Erythroplasia / genetics
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Erythroplasia / pathology
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Gene Expression*
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Genes, p53 / genetics
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Humans
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Immunoenzyme Techniques
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Ki-67 Antigen
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Leukoplakia, Oral / chemistry*
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Leukoplakia, Oral / genetics
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Leukoplakia, Oral / pathology
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Lymph Nodes / pathology
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Mouth Mucosa / chemistry*
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Mouth Mucosa / cytology
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Mouth Neoplasms / chemistry*
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Mouth Neoplasms / genetics
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Mouth Neoplasms / pathology
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Neoplasm Recurrence, Local
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Nuclear Proteins / analysis
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Smoking / genetics
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Smoking / metabolism
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Survival Rate
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Tumor Suppressor Protein p53 / analysis*
Substances
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Antibodies, Monoclonal
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Epitopes
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Ki-67 Antigen
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Nuclear Proteins
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Tumor Suppressor Protein p53