Abstract
Using a fragment of the cDNA for human coagulation factor VIII as a hybridization probe, we have detected a new polymorphic HindIII site in intron 19 of the factor VIII gene. The frequency of the minor allele is 0.30. This polymorphism shows strong linkage disequilibrium with a previously described BclI polymorphism in intron 18.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Chromosome Mapping
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DNA / genetics
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DNA Restriction Enzymes*
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Deoxyribonuclease HindIII
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Factor VIII / genetics*
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Female
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Hemophilia A / genetics*
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Humans
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Introns
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Male
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Polymorphism, Genetic*
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Polymorphism, Restriction Fragment Length*
Substances
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Factor VIII
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DNA
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DNA Restriction Enzymes
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Deoxyribonuclease HindIII