The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma

Neurosci Lett. 1988 Oct 31;93(1):114-9. doi: 10.1016/0304-3940(88)90022-5.

Abstract

Expression of insulin-like growth factor I (IGF-I) and insulin-like growth factor II (IGF-II) genes in the human brain and in glioma was studied by slot blot and Northern analysis following hybridization of IGF-I and IGF-II cDNA probes to isolated mRNA. In the fetal brain there were major IGF-I transcripts of 7.5 and 4.4 kilobases (kb) and one major IGF-II transcript of 6.0 kb. IGF-II mRNA was less abundant in the adult brain, with IGF-II mRNA being scarcely detectable. All glioma tissue examined displayed a marked enhancement of both IGF-I and IGF-II gene expression when compared to normal brain. IGF-I transcripts of 4.4 and 2.2-1.8 kb were identified. Similar to fetal brain a major IGF-II transcript of 6.0 kb was found in the glioblastoma examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / embryology
  • Brain / metabolism*
  • Brain Neoplasms / metabolism*
  • Gene Expression Regulation*
  • Gestational Age
  • Glioma / metabolism*
  • Humans
  • Insulin-Like Growth Factor I / genetics*
  • Insulin-Like Growth Factor I / metabolism
  • Insulin-Like Growth Factor II / genetics*
  • Insulin-Like Growth Factor II / metabolism
  • Nucleic Acid Hybridization
  • RNA, Messenger / metabolism
  • Somatomedins / genetics*

Substances

  • RNA, Messenger
  • Somatomedins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II