Abstract
Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Amino Acid Sequence
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Base Sequence
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Chromosomes, Human, Pair 6
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Diabetes Mellitus, Type 1 / genetics*
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Disease Susceptibility
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Genetic Linkage
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HLA-D Antigens / genetics*
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HLA-DQ Antigens / genetics*
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HLA-DR Antigens / genetics
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Haploidy
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Histocompatibility Antigens Class II / genetics
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Humans
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Immunity, Innate
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Islets of Langerhans / immunology
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Molecular Sequence Data
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Oligonucleotides / analysis
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Polymorphism, Genetic
Substances
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HLA-D Antigens
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HLA-DQ Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II
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Oligonucleotides