Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides

Biochemistry. 1974 Feb 26;13(5):926-33. doi: 10.1021/bi00702a016.
No abstract available

MeSH terms

  • Amides
  • Binding Sites
  • Binding, Competitive
  • Carbon Radioisotopes
  • Cysteine / isolation & purification
  • Deoxyribonucleotides / metabolism
  • Drug Resistance, Microbial
  • Fluorine / metabolism
  • Iodoacetates
  • Kinetics
  • Lacticaseibacillus casei / enzymology*
  • Methotrexate
  • Methyltransferases / metabolism*
  • Models, Chemical
  • Peptide Fragments
  • Protein Binding
  • Protein Denaturation
  • Spectrophotometry, Ultraviolet
  • Structure-Activity Relationship
  • Tetrahydrofolates / metabolism
  • Tetrahydrofolates / pharmacology
  • Thymidylate Synthase / antagonists & inhibitors
  • Thymidylate Synthase / metabolism
  • Tritium
  • Trypsin
  • Uracil Nucleotides / metabolism*

Substances

  • Amides
  • Carbon Radioisotopes
  • Deoxyribonucleotides
  • Iodoacetates
  • Peptide Fragments
  • Tetrahydrofolates
  • Uracil Nucleotides
  • Tritium
  • Fluorine
  • Methyltransferases
  • Thymidylate Synthase
  • Trypsin
  • Cysteine
  • Methotrexate