Molecular breakpoints of t(11;14)(q13;q32) in multiple myeloma

P Meeus; M S Stul; C Mecucci; J J Cassiman; H Van den Berghe

doi:10.1016/s0165-4608(94)00211-8

Molecular breakpoints of t(11;14)(q13;q32) in multiple myeloma

Cancer Genet Cytogenet. 1995 Aug;83(1):25-7. doi: 10.1016/s0165-4608(94)00211-8.

Authors

P Meeus¹, M S Stul, C Mecucci, J J Cassiman, H Van den Berghe

Affiliation

¹ Center for Human Genetics, University of Leuven, Belgium.

PMID: 7656199
DOI: 10.1016/s0165-4608(94)00211-8

Abstract

We found a t(11;14)(q13;q32) translocation in six patients with multiple myeloma (MM) or plasma cell leukemia. In five of them, rearrangements of BCL1 and PRAD1 could be studied. Two patients showed a rearrangement only with the Prad1 probe, located 120 kb telomeric of the major translocation cluster. The three other patients lacked rearrangements with both Bcl1 and Prad1.

Publication types

Case Reports

MeSH terms

Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 14*
Humans
Karyotyping
Male
Middle Aged
Multiple Myeloma / genetics*
Translocation, Genetic*