The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action

Structure. 1995 Jan 15;3(1):1-6. doi: 10.1016/S0969-2126(01)00129-0.

Abstract

Both the observed cis-inhibition and the proposed trans-activation of the insulin receptor tyrosine kinase help explain insulin signalling through its receptor.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Humans
  • Insulin / physiology*
  • Models, Molecular
  • Protein Conformation*
  • Protein Structure, Secondary
  • Receptor, Insulin / biosynthesis
  • Receptor, Insulin / chemistry*
  • Receptor, Insulin / physiology

Substances

  • Insulin
  • Receptor, Insulin