Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome

N McClure; D L Healy; P A Rogers; J Sullivan; L Beaton; R V Haning Jr; D T Connolly; D M Robertson

doi:10.1016/s0140-6736(94)93001-5

Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome

Lancet. 1994 Jul 23;344(8917):235-6. doi: 10.1016/s0140-6736(94)93001-5.

Authors

N McClure¹, D L Healy, P A Rogers, J Sullivan, L Beaton, R V Haning Jr, D T Connolly, D M Robertson

Affiliation

¹ Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Victoria, Australia.

PMID: 7913160
DOI: 10.1016/s0140-6736(94)93001-5

Abstract

We investigated the role of vascular endothelial growth factor (VEGF) in ovarian hyperstimulation syndrome (OHSS). Two similar peaks of permeability activity were seen in OHSS ascites and liver ascites spiked with recombinant human VEGF (rhVEGF); no activity was seen in control liver ascites. Incubation with rhVEGF antiserum decreased activity in the two OHSS peaks by 79% and 65% and the two spiked liver peaks by 49% and 50%. Control serum produced 24% and 27%, and 17% and 0% reductions, respectively. This is evidence that the major capillary permeability agent in OHSS ascites fluid is VEGF.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Ascites / etiology
Ascites / physiopathology
Ascitic Fluid / chemistry
Capillary Permeability / physiology*
Endothelial Growth Factors / analysis
Endothelial Growth Factors / physiology*
Female
Guinea Pigs
Humans
Liver Failure / complications
Lymphokines / analysis
Lymphokines / physiology*
Ovarian Hyperstimulation Syndrome / complications
Ovarian Hyperstimulation Syndrome / physiopathology*
Recombinant Proteins
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors

Substances

Endothelial Growth Factors
Lymphokines
Recombinant Proteins
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors