Apoptosis--molecular mechanisms and biomedical implications

D J McConkey; B Zhivotovsky; S Orrenius

doi:10.1016/0098-2997(95)00006-2

Apoptosis--molecular mechanisms and biomedical implications

Mol Aspects Med. 1996 Feb;17(1):1-110. doi: 10.1016/0098-2997(95)00006-2.

Authors

D J McConkey¹, B Zhivotovsky, S Orrenius

Affiliation

¹ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

PMID: 8783196
DOI: 10.1016/0098-2997(95)00006-2

Abstract

Apoptosis is a distinct form of cell death of importance in tissue development and homeostasis and in several diseases. This review summarizes current knowledge about the regulation and molecular mechanisms of apoptosis and discusses the potential role of disregulated apoptosis in several major diseases. Finally, we speculate that modulation of apoptosis may be a target in future drug therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis / physiology*
Central Nervous System / cytology
Central Nervous System / growth & development
Clonal Deletion
Disease / etiology*
Gene Expression Regulation
Immune System / cytology
Immune System / growth & development
Immune System Diseases / physiopathology
Models, Biological
Neoplasms / physiopathology
Signal Transduction
Thymus Gland / cytology
Thymus Gland / growth & development