Abstract
Synthesis of eukaryotic messenger RNA by RNA polymerase II is governed by the concerted action of a set of general transcription factors that control the activity of polymerase during both the initiation and elongation stages of transcription. To date, five general elongation factors [P-TEFb, SII, TFIIF, Elongin (SIII) and ELL] have been defined biochemically. Here, we discuss these transcription factors and their roles in controlling the activity of the RNA polymerase II elongation complex.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
DNA-Binding Proteins / genetics
-
DNA-Binding Proteins / metabolism
-
Elongin
-
Neoplasm Proteins*
-
Peptide Elongation Factors*
-
Protein Biosynthesis
-
RNA Polymerase II / genetics
-
RNA Polymerase II / metabolism*
-
Transcription Factors / genetics*
-
Transcription Factors / metabolism*
-
Transcription Factors, General*
-
Transcription Factors, TFII*
-
Transcription, Genetic
-
Transcriptional Elongation Factors*
Substances
-
DNA-Binding Proteins
-
ELL protein, human
-
Elongin
-
Neoplasm Proteins
-
Peptide Elongation Factors
-
Transcription Factors
-
Transcription Factors, General
-
Transcription Factors, TFII
-
Transcriptional Elongation Factors
-
transcription factor S-II
-
RNA Polymerase II
-
transcription factor TFIIF