Abstract
A cell-death signaling system has been described recently that involves the ligand TRAIL and corresponding TRAIL-specific cell-surface receptors. These include two receptors able to transduce a death signal and, as a previously unsuspected control mechanism, two other receptors able to prevent this transduction.
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Animals
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Apoptosis Regulatory Proteins
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Apoptosis*
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Carrier Proteins / metabolism
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Fas-Associated Death Domain Protein
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GPI-Linked Proteins
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Humans
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Membrane Glycoproteins / metabolism*
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Receptors, TNF-Related Apoptosis-Inducing Ligand
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Receptors, Tumor Necrosis Factor / metabolism*
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Receptors, Tumor Necrosis Factor, Member 10c
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TNF-Related Apoptosis-Inducing Ligand
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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Carrier Proteins
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FADD protein, human
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Fas-Associated Death Domain Protein
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GPI-Linked Proteins
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Membrane Glycoproteins
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Receptors, TNF-Related Apoptosis-Inducing Ligand
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Member 10c
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TNF-Related Apoptosis-Inducing Ligand
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TNFRSF10A protein, human
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TNFRSF10B protein, human
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TNFRSF10C protein, human
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TNFSF10 protein, human
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha