Abstract
Beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Cell Adhesion
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Cytoskeletal Proteins / chemistry
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Cytoskeletal Proteins / metabolism
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Cytoskeletal Proteins / physiology*
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DNA-Binding Proteins / metabolism
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Drosophila Proteins*
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Humans
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Lymphoid Enhancer-Binding Factor 1
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Proto-Oncogene Proteins / metabolism*
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Signal Transduction*
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Trans-Activators*
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Transcription Factors / metabolism
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Wnt1 Protein
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beta Catenin
Substances
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CTNNB1 protein, human
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Cytoskeletal Proteins
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DNA-Binding Proteins
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Drosophila Proteins
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Lymphoid Enhancer-Binding Factor 1
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Proto-Oncogene Proteins
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Trans-Activators
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Transcription Factors
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Wnt1 Protein
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beta Catenin
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wg protein, Drosophila