While the plasticity of excitatory synaptic connections in the brain has been widely studied,
the plasticity of inhibitory connections is much less understood. Here, we present recent …

Brain function relies on the ability of neural networks to maintain stable levels of activity,
while experiences sculpt them. In the neocortex, the balance between activity and stability …

The insular cortex is the primary cortical site devoted to taste processing. A large body of
evidence is available for how insular neurons respond to gustatory stimulation in both …

The G protein-coupled, receptor-activated phosphoinositide 3-kinase γ (PI3Kγ) mediates
inflammatory responses and negatively controls cardiac contractility by reducing cAMP …

Rett Syndrome (RTT) is a devastating neurological disorder that is caused by mutations in
the MECP2 gene. Mecp2-mutant mice have been used as a model system to study the …

Recent evidence suggests that besides its action on the central nervous system, leptin can
modulate vascular tone through local mechanisms involving nitric oxide (NO) release. In this …

TGF-β proteins are main regulators of blood vessel development and maintenance. Here,
we report an unprecedented link between TGF-β signaling and arterial hypertension based …

Visual deprivation during a developmental sensitive period markedly alters visual cortical
response properties, but the changes in intracortical circuitry that underlie these effects are …

The fine-tuning of circuits in sensory cortex requires sensory experience during an early
critical period. Visual deprivation during the critical period has catastrophic effects on visual …

Neurons process information in a highly nonlinear manner, generating oscillations, bursting,
and resonance, enhancing responsiveness at preferential frequencies. It has been …