Hyalograft® C is an innovative tissue‐engineering approach for the treatment of knee
cartilage defects involving the implantation of laboratory expanded autologous chondrocytes …

An analysis of the mechanics and energetics of swimming reveals that different factors play
key roles in success in competitive swimming events. Knowledge of these performance …

Background The loss of a normal airway is devastating. Attempts to replace large airways
have met with serious problems. Prerequisites for a tissue-engineered replacement are a …

Cartilage is considered to be a simple tissue that should be easy to engineer because it is
avascular and contains just one cell type, the chondrocyte. Despite this apparent simplicity …

Very little is known about the turnover of extracellular matrix in the human intervertebral disc.
We measured concentrations of specific molecules reflecting matrix synthesis and …

A new immunoassay was developed to detect denaturation of type II collagen in
osteoarthritis (OA). A peptide, alpha 1 (II)-CB11B, located in the CB11 peptide of type II …

Enhanced denaturation of type II collagen fibrils in femoral condylar cartilage in
osteoarthritis (OA) has recently been quantitated immunochemically (Hollander, AP, TF …

Cathepsin K (EC 3.4. 22.38) is a recently described enzyme that has been shown to cleave
type I collagen in its triple helix. The aim of this study was to determine if it also cleaves type …

Background & Aims: The expression of matrix metalloproteinases 1, 2, 3, and 9 was
examined in biopsy specimens removed from adult and pediatric patients with ulcerative …

Chondrogenesis was studied under controlledin vitroconditions using a cell-polymer-
bioreactor system. Bovine calf articular chondrocytes were seeded onto biodegradable …