Human tumour necrosis factor has about 30% homology in its amino acid sequence with
lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour …

Bacterial clones containing human tissue-type plasminogen activator (t-PA) cDNA
sequences were identified in a cDNA library prepared using gel-fractionated mRNA from …

Abstract The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate
development. Here we demonstrate that it binds Patched (vPtc), which has been identified …

Herein we report the generation of mice lacking the ubiquitously expressed Janus kinase,
Jak1. Jak1−/− mice are runted at birth, fail to nurse, and die perinatally. Although Jak1 …

Abstract Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have
similar biological activities and share 30 percent amino acid homology. The single copy …

Wnt family members are critical to many developmental processes, and components of the
Wnt signaling pathway have been linked to tumorigenesis in familial and sporadic colon …

Heart failure continues to be a leading cause of mortality worldwide. A hallmark of this
disease is dilated cardiac hypertrophy, which is accompanied by a reactivation of genes …

To understand the role of the 75-kDa tumor necrosis factor (TNF) receptor in non-lymphoid
cells, the cytotoxic signaling and ligand binding activities of the 55-kDa (TNF-R1) and 75 …

A cDNA sequence coding for human immune interferon (IFN-γ) has been identified in a
cDNA library prepared from gel-fractionated IFN-γ mRNA. The DNA sequence codes for a …

Cardiotrophin-1 (CT-1) is a newly isolated cytokine that was identified based on its ability to
induce cardiac myocyte hypertrophy. It is a member of the family of cytokines that includes …