Langerhans cells (LCs) constitute a subset of dendritic cells (DCs) that express the lectin
langerin and that reside in their immature state in epidermis. Paradoxically, in mice …

Recent studies have challenged the view that Langerhans cells (LCs) constitute the
exclusive antigen-presenting cells of the skin and suggest that the dermal dendritic cell …

Small intestinal CD103+ dendritic cells (DCs) have the selective ability to promote de novo
generation of regulatory T cells via the production of retinoic acid (RA). Considering that …

DNAX accessory molecule 1 (DNAM-1; CD226) is a transmembrane glycoprotein involved
in T cell and natural killer (NK) cell cytotoxicity. We demonstrated recently that DNAM-1 …

Until now it was assumed that the murine poliovirus (PV) receptor homolog gene (MPH) had
been identified. Alternative splicing of MPH transcripts generates two glycoproteins named …

The classification of peripheral T-cell lymphomas (PTCL) is still a matter of debate. To
establish a molecular classification of PTCL, we analysed 59 primary nodal T-cell …

Control of pulmonary pathogens constitutes a challenging task as successful immune
responses need to be mounted without damaging the lung parenchyma. Using …

The extensive heterogeneity of breast cancer complicates the precise assessment of tumour
aggressiveness, making therapeutic decisions difficult and treatments inappropriate in some …

Although the prognosis of Hodgkin's disease is relatively good, around 20% of patients do
not benefit from current therapies and succumb to their disease. A large-scale molecular …

AIMS: To confirm the recent data obtained in mice, showing that the Fas ligand (FasL) is
involved in the phenomenon of" immune privilege"(the apparent defect of the immune …