In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of
function may be mediated by irreversible processes such as gene deletion or mutation …

Wolfram syndrome (WS) is the inherited association of juvenile‐onset insulin‐dependant
diabetes mellitus and progressive bilateral optic atrophy. A nuclear gene, WFS1/wolframin …

A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL)
disease tumor suppressor gene. A restriction fragment encompassing the gene showed …

Multiple, bilateral renal carcinomas are a frequent occurrence in von Hippel–Lindau (VHL)
disease. To elucidate the aetiological role of the VHL gene in human kidney tumorigenesis …

The pheochromocytomas are an important cause of secondary hypertension. Although
pheochromocytoma susceptibility may be associated with germline mutations in the tumor …

Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be
causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that …

Background: The recently identified RASSF1 locus is located within a 120-kilobase region of
chromosome 3p21. 3 that frequently undergoes allele loss in lung and breast cancers. We …

Abstract Von Hippel‐Lindau disease (VHL) is an inherited neoplastic disease characterized
by a predisposition to develop retinal angiomas, central nervous system …

Allele loss involving chromosome arm 3p is one of the most frequent and earliest known
genetic events in lung cancer pathogenesis and may affect several potential tumor …