BACKGROUND AND OBJECTIVES: The CD4+ CD56+ lin-immunophenotype characterizes
rare malignancies, so far considered as arising from the transformation of NK progenitors …

An abnormal neutrophil subset has been identified in the PBMC fractions from lupus
patients. We have proposed that these low-density granulocytes (LDGs) play an important …

To assess the sensitivity of primary non-Hodgkin lymphoma cells to rituximab-mediated
cytotoxicity, we compared the potency of several rituximab-mediated killing mechanisms on …

Mesenchymal stem cells (MSC) have recently been used successfully in humans to control
severe graft-versus-host disease. However, the mechanisms involved in their …

This work aims to demonstrate that CD4+ CD56+ malignancies arise from transformed cells
of the lymphoid-related plasmacytoid dendritic cell (pDC) subset. The analysis of malignant …

Toll-like receptor 9 (TLR9) senses microbial DNA and triggers type I IFN responses in
plasmacytoid dendritic cells (pDCs). Previous studies suggest the presence of myeloid …

Among dendritic cells, plasmacytoid dendritic cells (PDC) represent a functionally distinct
lineage. Regarding innate immunity, PDC secrete large amounts of type I IFN upon viral …

Melanoma is a cutaneous cancer with an increasing worldwide prevalence and high
mortality due to unresectable or metastatic stages. Mutations in BRAF, NRAS, or KIT are …

Plasmacytoid DCs (pDCs) have been implicated as crucial cells in antiviral immune
responses. On recognizing HIV, they become activated, secreting large amounts of IFN-α …

Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We
examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells …