cis-diamminedichloroplatinum (II) or cisplatin is a DNA-damaging agent that is widely used
in cancer chemotherapy. Cisplatin cross-links to DNA, forming intra-and interstrand adducts …

Compartmentalization has long been known to have a key role in regulation of cellular
processes. By keeping enzymes and regulatory complexes in compartments where the …

Next-generation sequencing has revolutionized clinical diagnostic testing. Yet, for a
substantial proportion of patients, sequence information restricted to exons and exon–intron …

Transcription is a highly dynamic process. Consequently, we have developed native
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which …

Acute promyelocytic leukemia (APL) is characterized by a specific t (l5; 17) translocation that
fuses the retinoic acid receptor a (RAFta) to a novel gene product, PML. The involvement of …

Messenger RNAs are exported from the nucleus as large ribonucleoprotein complexes
(mRNPs). To date, proteins implicated in this process include TAP/Mex67p and RAE1/Gle2p …

We have recently shown that discrete foci are present in the nuclei of mammalian cells in
which each of the U1, U2, U4/U6, and U5 snRNPs involved in pre-mRNA splicing, and the …

ADAR1 and ADAR2 are editing enzymes that deaminate adenosine to inosine in long
double stranded RNA duplexes and specific pre-mRNA transcripts. Here, we show that full …

Vesicular stomatitis virus matrix protein (VSV M) has been shown to inhibit both transcription
and nucleocytoplasmic transport. We have isolated a mutant form of M, termed M (D) …

Dbp5 is a DEAD‐box protein essential for mRNA export from the nucleus in yeast. Here we
report the isolation of a cDNA encoding human Dbp5 (hDbp5) which is 46% identical to …