Marine heatwaves
Ocean temperature variability is a fundamental component of the Earth's climate system, and
extremes in this variability affect the health of marine ecosystems around the world. The …
extremes in this variability affect the health of marine ecosystems around the world. The …
[HTML][HTML] Phosphatidylserine, a death knell
RA Schlegel, P Williamson - Cell Death & Differentiation, 2001 - nature.com
Virtually every cell in the body restricts phosphatidylserine (PS) to the inner leaflet of the
plasma membrane by energy-dependent transport from the outer to the inner leaflet of the …
plasma membrane by energy-dependent transport from the outer to the inner leaflet of the …
Apoptosis and the cell cycle
W Meikrantz, R Schlegel - Journal of cellular biochemistry, 1995 - Wiley Online Library
In this review, we consider apoptosis as a process intimately linked to the cell cycle. There
are several reasons for thinking of apoptosis as a cell cycle phenomenon. First, within the …
are several reasons for thinking of apoptosis as a cell cycle phenomenon. First, within the …
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
The systematic translation of cancer genomic data into knowledge of tumour biology and
therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust …
therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust …
Next-generation characterization of the cancer cell line encyclopedia
…, MP Morrissey, F Stegmeier, R Schlegel… - Nature, 2019 - nature.com
Large panels of comprehensively characterized human cancer models, including the
Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to …
Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to …
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
…, R Dummer, BL Weber, WR Sellers, R Schlegel… - Nature, 2010 - nature.com
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found
in 50–70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF …
in 50–70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF …
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes
The early human papillomavirus type 16 genes that directly participate in the in vitro
transformation of primary human keratinocytes have been defined. In the context of the full …
transformation of primary human keratinocytes have been defined. In the context of the full …
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
…, EM Sanford, S Roels, J White, J Greshock, R Schlegel… - Cancer discovery, 2015 - AACR
Focal amplification and activating point mutation of the MET gene are well-characterized
oncogenic drivers that confer susceptibility to targeted MET inhibitors. Recurrent somatic …
oncogenic drivers that confer susceptibility to targeted MET inhibitors. Recurrent somatic …
Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis
…, L Tarcsay, G Zwadlo, G Gerhards, R Schlegel… - Nature, 1987 - nature.com
The aetiology and cellular mechanism of chronic inflammatory processes are poorly
understood. Macrophages act prominently in the inflammatory response and we report here …
understood. Macrophages act prominently in the inflammatory response and we report here …
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
…, I Krishnan-Hewlett, CC Baker, R Schlegel… - The American journal …, 1985 - ncbi.nlm.nih.gov
A series of human carcinoma cell lines was examined for human papillomavirus (HPV) DNA
sequences with the use of HPV-6, HPV-11, HPV-16, and HPV-18 DNA probes. Six of eight …
sequences with the use of HPV-6, HPV-11, HPV-16, and HPV-18 DNA probes. Six of eight …