Alterations of the length of simple repetitive genomic sequences (microsatellite instability,
MSI) characterize a distinct mechanism of colorectal carcinogenesis. Such MSI has been …

Multifocal hyperplasia of interstitial cells of Cajal (ICC hyperplasia) is a precursor of
hereditary gastrointestinal stromal tumors (GISTs) in patients with germline mutations of c …

Combining whole genome amplification (WGA) methods with novel laser-based
microdissection techniques has made it possible to exploit recent progress in molecular …

Purpose Patients with Lynch syndrome are at high risk for colon and endometrial cancer, but
also at an elevated risk for other less common cancers. The purpose of this retrospective …

Background: Eph receptors and their ligands, the ephrins, represent a large class of cell–cell
communication molecules with well-defined developmental functions. Their role in healthy …

The adoptive transfer of CD4+ CD25+ natural regulatory T cells (Treg) is a promising
strategy for the treatment of autoimmune diseases and the prevention of alloresponses after …

BACKGROUND Doxorubicin exhibits high efficacy in malignant glioma cell cultures.
Nonetheless, as a standard formulation, doxorubicin has not been used clinically, due to …

Background: The prognosis of metastatic non-small cell lung cancer (NSCLC) is still poor.
Activating epithelial growth factor receptor (EGFR) mutations are important genetic …

Multifocality and recurrence of urothelial carcinoma may result from either the field effect of
carcinogens leading to oligoclonal tumors or monoclonal tumor spread. Previous molecular …

Background Lung cancer has emerged as a global public health problem and is the most
common cause of cancer deaths by absolute cases globally. Besides tobacco, smoke …