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The aetiology of idiopathic Parkinson's disease
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  1. D B Ramsden1,
  2. R B Parsons1,
  3. S L Ho2,
  4. R H Waring3
  1. 1Department of Medicine, Division of Medical Science, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
  2. 2Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China
  3. 3School of Biochemistry, University of Birmingham
  1. Dr Ramsden D.B.Ramsden{at}bham.ac.uk

Abstract

Agents potentially involved in the aetiology of idiopathic Parkinson's disease are discussed. These include factors regulating dopaminergic neurogenesis (Nurr 1, Ptx-3, and Lmx1b) and related proteins, together with genes involved in familial Parkinson's disease (α synuclein, parkin, and ubiquitin carboxy terminal hydroxylase L1), and endogenous and environmental agents.

  • Parkinson's disease
  • environmental agents
  • transcription factors
  • α synuclein
  • parkin
  • ubiquitin carboxy terminal hydroxylase L1
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