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Cyclin E and chromosome instability in colorectal cancer cell lines
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  1. C Simone1,
  2. N Resta1,
  3. L Bagella2,
  4. A Giordano2,
  5. G Guanti1
  1. 1Department of Internal and Public Medicine, Division of Medical Genetics, University of Bari, Bari 70124, Italy
  2. 2Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
  1. Correspondence to:
 Dr C Simone, Department of Public Medicine, Division of Medical Genetics, University of Bari, Bari 70124, Italy;
 cristianosimone{at}hotmail.com

Abstract

Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes.

Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines.

Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a significant increase in protein concentrations.

Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway.

  • cyclin dependent kinase
  • cyclin
  • chromosome instability
  • colorectal cancer
  • aneuploidy
  • cdk, cyclin dependent kinase
  • CIN, chromosome instability
  • hFSF, human fetal skin fibroblasts
  • MIN, microsatellite instability
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