Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes.
Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines.
Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a significant increase in protein concentrations.
Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway.
- cyclin dependent kinase
- chromosome instability
- colorectal cancer
- cdk, cyclin dependent kinase
- CIN, chromosome instability
- hFSF, human fetal skin fibroblasts
- MIN, microsatellite instability
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