The ability of multipotential adult stem cells to cross lineage boundaries (transdifferentiate) is currently causing heated debate in the scientific press. The proponents see adult stem cells as an attractive alternative to the use of embryonic stem cells in regenerative medicine (the treatment of diabetes, Parkinson’s disease, etc). However, opponents have questioned the very existence of the process, claiming that cell fusion is responsible for the phenomenon. This review sets out to provide a critical evaluation of the current literature in the adult stem cell field.
- bone marrow
- stem cells
- CNS, central nervous system
- ES, embryonic stem
- FAH, fumarylacetoacetate hydrolase
- G-CSF, granulocyte colony stimulating factor
- HSC, haemopoietic stem cell
- ISEMF, intestinal subepithelial myofibroblasts
- KGF, keratinocyte growth factor
- MSC, mesenchymal stem cell
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.