You are here

Article Text

Article menu
Download PDFPDF
Correspondence
Tumour necrosis factor microsatellite association with human papillomavirus cervical infection
  1. R T Simões1,
  2. J S R Bettini1,
  3. E G Soares1,
  4. G Duarte2,
  5. M A G Gonçalves3,
  6. A L Simões4
  1. 1Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049–900, Ribeirão Preto, SP–Brazil
  2. 2Department of Gynecology and Obstetrics, School of Medicine of Ribeirão Preto
  3. 3Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto
  4. 4Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049–900, Ribeirão Preto, SP–Brazil; alsimoes@fmrp.usp.br

    https://doi.org/10.1136/mp.56.5.305

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

      Cervical cancer is the second most common cancer in the female population worldwide, and human papillomavirus (HPV) DNA has been isolated from more than 90% of these carcinomas. Immunoregulatory/antitumour mechanisms include cytokines that interfere directly with HPV harbouring cells. Among these cytokines, tumour necrosis factor α (TNFα) is released by HPV infected cells and inhibits the growth of transformed cell lines.1

      TNFα is a proinflammatory/antitumour cytokine that is indispensable to the inflammatory response. The TNF locus contains several polymorphic areas, including five microsatellite markers—a, b, c, d, and e—which contain 14, 7, 2, 7, and 3 alleles, respectively. These microsatellites are associated with different degrees of TNFα secretion, and are related to a greater susceptibility to …

      View Full Text