@article {Kelly1, author = {M A Kelly and M L Rayner and C H Mijovic and A H Barnett}, title = {Molecular aspects of type 1 diabetes}, volume = {56}, number = {1}, pages = {1--10}, year = {2003}, doi = {10.1136/mp.56.1.1}, publisher = {BMJ Publishing Group Ltd}, abstract = {Type 1 diabetes is a T cell mediated autoimmune disease, characterised by the selective destruction of pancreatic β cells, and susceptibility is determined by a combination of genetic and environmental factors. The environmental agents implicated include viruses and dietary factors, although none has yet been shown to be directly responsible for triggering β cell autoimmunity. The genetic factors that influence disease risk have been subjected to more intensive study and two gene regions of major importance have been identified: the human leucocyte antigen locus and the insulin gene. This review will focus on the mechanisms by which these genes might influence the risk of developing type 1 diabetes.}, issn = {1366-8714}, URL = {https://mp.bmj.com/content/56/1/1}, eprint = {https://mp.bmj.com/content/56/1/1.full.pdf}, journal = {Molecular Pathology} }