RT Journal Article
SR Electronic
T1 Progeroid syndromes: probing the molecular basis of aging?
JF Molecular Pathology
JO Mol Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 234
OP 241
DO 10.1136/mp.50.5.234
VO 50
IS 5
A1 D Kipling
A1 R G Faragher
YR 1997
UL http://mp.bmj.com/content/50/5/234.abstract
AB A valid method of studying age related degenerative pathologies is to study human genetic diseases that appear to accelerate many, though not necessarily all, features of the aging process. Such diseases are described as progeroid syndromes because of their possible relevance to many aspects of aging and age related disease. This article describes the recent progress made at the cellular and molecular levels in understanding the pathogenesis of one of the best characterised of these disorders, Werner's syndrome. These observations are related to some of the less well characterised progeroid syndromes within the context of the cell senescence hypothesis of aging, a theory formulated to explain the aging of regenerative tissue in normal individuals.