PT - JOURNAL ARTICLE AU - R L Stephen AU - J E Crabtree AU - T Yoshimura AU - C L Clayton AU - M F Dixon AU - P A Robinson TI - Increased zinc finger protein zFOC1 transcripts in gastric cancer compared with normal gastric tissue AID - 10.1136/mp.56.3.167 DP - 2003 Jun 01 TA - Molecular Pathology PG - 167--171 VI - 56 IP - 3 4099 - http://mp.bmj.com/content/56/3/167.short 4100 - http://mp.bmj.com/content/56/3/167.full SO - Mol Pathol2003 Jun 01; 56 AB - Background: Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori. Aims: To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer. Results: zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOCI gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues. Conclusions: The zFOC1 gene appears to be a tumour marker associated with gastric cancer.