RT Journal Article
SR Electronic
T1 Increased zinc finger protein zFOC1 transcripts in gastric cancer compared with normal gastric tissue
JF Molecular Pathology
JO Mol Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 167
OP 171
DO 10.1136/mp.56.3.167
VO 56
IS 3
A1 R L Stephen
A1 J E Crabtree
A1 T Yoshimura
A1 C L Clayton
A1 M F Dixon
A1 P A Robinson
YR 2003
UL http://mp.bmj.com/content/56/3/167.abstract
AB Background: Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori. Aims: To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer. Results: zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOCI gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues. Conclusions: The zFOC1 gene appears to be a tumour marker associated with gastric cancer.