TY - JOUR T1 - Leukaemic mantle cell lymphoma with t(11;14) and trisomy 12 showing clinical features of state A0 B cell chronic lymphocytic leukaemia JF - Clinical Molecular Pathology JO - Clin Mol Pathol SP - M165 LP - M166 DO - 10.1136/mp.48.3.M165 VL - 48 IS - 3 AU - J R Neilson AU - M Cai AU - N Bienz AU - M J Leyland Y1 - 1995/06/01 UR - http://mp.bmj.com/content/48/3/M165.abstract N2 - The precise diagnosis of lymphoma usually requires the histological examination of lymph nodes or involved tissues. Mantle cell lymphoma is a form of intermediate grade non-Hodgkin's lymphoma in which typical morphological immunophenotypic and cytogenetic features have been recognised. A case of leukaemic mantle cell lymphoma with the characteristic reciprocal translocation t(11;14) together with trisomy 12, a chromosomal abnormality usually associated with B cell chronic lymphocytic leukaemia (CLL), is presented. This combination of cytogenetic abnormalities has not been reported previously. The lack of lymphadenopathy and hepatosplenomegaly in this patient is more in keeping with stage A0 CLL. This case demonstrates the close clinical and biological relationship between mantle cell lymphoma and CLL. ER -