RT Journal Article
SR Electronic
T1 Leukaemic mantle cell lymphoma with t(11;14) and trisomy 12 showing clinical features of state A0 B cell chronic lymphocytic leukaemia
JF Clinical Molecular Pathology
JO Clin Mol Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP M165
OP M166
DO 10.1136/mp.48.3.M165
VO 48
IS 3
A1 J R Neilson
A1 M Cai
A1 N Bienz
A1 M J Leyland
YR 1995
UL http://mp.bmj.com/content/48/3/M165.abstract
AB The precise diagnosis of lymphoma usually requires the histological examination of lymph nodes or involved tissues. Mantle cell lymphoma is a form of intermediate grade non-Hodgkin's lymphoma in which typical morphological immunophenotypic and cytogenetic features have been recognised. A case of leukaemic mantle cell lymphoma with the characteristic reciprocal translocation t(11;14) together with trisomy 12, a chromosomal abnormality usually associated with B cell chronic lymphocytic leukaemia (CLL), is presented. This combination of cytogenetic abnormalities has not been reported previously. The lack of lymphadenopathy and hepatosplenomegaly in this patient is more in keeping with stage A0 CLL. This case demonstrates the close clinical and biological relationship between mantle cell lymphoma and CLL.