TY - JOUR T1 - The adenomatous polyposis coli protein. JF - Molecular Pathology JO - Mol Pathol SP - 169 LP - 173 DO - 10.1136/mp.52.4.169 VL - 52 IS - 4 AU - I S Näthke Y1 - 1999/08/01 UR - http://mp.bmj.com/content/52/4/169.abstract N2 - Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis. ER -