RT Journal Article
SR Electronic
T1 The adenomatous polyposis coli protein.
JF Molecular Pathology
JO Mol Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 169
OP 173
DO 10.1136/mp.52.4.169
VO 52
IS 4
A1 I S Näthke
YR 1999
UL http://mp.bmj.com/content/52/4/169.abstract
AB Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.