@article {Simone200, author = {C Simone and N Resta and L Bagella and A Giordano and G Guanti}, title = {Cyclin E and chromosome instability in colorectal cancer cell lines}, volume = {55}, number = {3}, pages = {200--203}, year = {2002}, doi = {10.1136/mp.55.3.200}, publisher = {BMJ Publishing Group Ltd}, abstract = {Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes. Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines. Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a significant increase in protein concentrations. Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway.}, issn = {1366-8714}, URL = {https://mp.bmj.com/content/55/3/200}, eprint = {https://mp.bmj.com/content/55/3/200.full.pdf}, journal = {Molecular Pathology} }