%0 Journal Article %A C Simone %A N Resta %A L Bagella %A A Giordano %A G Guanti %T Cyclin E and chromosome instability in colorectal cancer cell lines %D 2002 %R 10.1136/mp.55.3.200 %J Molecular Pathology %P 200-203 %V 55 %N 3 %X Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes. Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines. Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a significant increase in protein concentrations. Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway. %U https://mp.bmj.com/content/molpath/55/3/200.full.pdf