TY - JOUR T1 - Cyclin E and chromosome instability in colorectal cancer cell lines JF - Molecular Pathology JO - Mol Pathol SP - 200 LP - 203 DO - 10.1136/mp.55.3.200 VL - 55 IS - 3 AU - C Simone AU - N Resta AU - L Bagella AU - A Giordano AU - G Guanti Y1 - 2002/06/01 UR - http://mp.bmj.com/content/55/3/200.abstract N2 - Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes. Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines. Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a significant increase in protein concentrations. Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway. ER -