RT Journal Article
SR Electronic
T1 Cyclin E and chromosome instability in colorectal cancer cell lines
JF Molecular Pathology
JO Mol Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 200
OP 203
DO 10.1136/mp.55.3.200
VO 55
IS 3
A1 C Simone
A1 N Resta
A1 L Bagella
A1 A Giordano
A1 G Guanti
YR 2002
UL http://mp.bmj.com/content/55/3/200.abstract
AB Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes. Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines. Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a significant increase in protein concentrations. Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway.